Master Thesis in the V. Jantsch Lab
We are looking for a dedicated and highly motivated student to study meiotic regulatory events
At meiosis onset, the two chromosome sets of the father and the mother need to find each other and undergo a physical linkeage, which ensures their subequent accurate segregation into two daughter cells. At the same time, genetic material is exchanged between parental chromosomes. The events leading to this physical likeage need to be tightly regulated and coordinated and they include eg. DNA double strand break induction, their repair by homologous recombination, chromosome movement and alignment of homologous chromosomes. Previously, we showed that loss of this coordination leads to missing links between homologous parental chromosomes, followed by chomosome mis-segregation, which leads to the generation of inviable offspring. Defects in meiotic cell divisions are the leading cause of miscarriages and diseases linked to mental retardation.
With this project we suggest to study the regulatory events that ensure proper meiotic entry and progression. We study a mutant, where the numerous events at meiotic prohpase are started prematurely. We use the genetic model system Caenorhabditis elegans, which allows us to combine cell biology with genetics and biochemistry. At the same time, the genes and factors involved in the regulation of meiosis are also found in mammalian systems, therefore allowing to transfer the knowledge gained in our study to higher organisms including humans.
Training requirement: studies of genetics or molecular biology. Work with C. elegans requires fine motoric skills. A stipend will be offered.
Department of Chromosome Biology
Max F. Perutz Laboratories
University of Vienna
Vienna Bio Center
Dr. Bohrgasse 9/5, A-1030 Vienna