Master’s thesis in Biochemistry/Structural Biology

27/12/2017

We are looking for a self-driven and highly motivated Master’s student with an interest in protein biochemistry and structural biology. The position will be available in the research group of Dea Slade at the Max F. Perutz Laboratories in Vienna.

 

Background
The C-terminal domain (CTD) of RNA polymerase II consists of heptarepeats of the residues Y1S2P3T4S5P6S7, five of which can be phosphorylated. Throughout the transcription cycle the phosphorylation pattern changes dynamically and orchestrates specific binding of transcription and RNA processing factors. We recently identified a new CTD-binding domain with a specificity for phospho-S2.

The Master’s thesis project will focus on the biochemical and structural characterization of similar domains from other proteins to determine their CTD-binding specificities. The project will involve recombinant protein expression, protein purification, binding assays and setting up crystallization trials to obtain X-ray structures.

Applicants should hold a BSc degree in Biochemistry, Molecular Biology or a related field. Since the working language in our lab is English, excellent written and oral communication skills in English are required. Previous experience in protein purification is a plus, but not essential. The position is available starting early 2018 for approximately one year. The successful candidate will receive a monthly stipend of about 400€.

If you are interested please send your application including a cover letter, your CV and the contact details of at least one referee to dea.slade [AT] univie.ac [DOT] at