GROUP KöHLER GOTTFRIED | Biochemistry & Biophysics, Structural & Computational Biology

Biomolecular optical spectroscopy

Gottfried KOEHLER
Gottfried Koehler
Group Leader

Phone: +43-1-4277-52204
Dr. Bohr-Gasse 9 (VBC 5), 1030 Vienna | Room: 1.616


Biophysical characterisation of biomolecules and of their interactions in solution as well as on a live cell level represents the main object of our research. Methods include fluorescence and time resolved techniques performed over a wide range of time resolution. Studies by optical spectroscopy are complemented by biocalorimetry (DSC).


Quantitative studies on molecular dynamics on a single molecule level are performed using advanced fluorescence correlation techniques. Among others, these methods are applied on studies of ligand-receptor interactions relevant for hormone regulation and...


Martin Gerald Puchinger| Aamir Shahzad|

Selected Publications

Michael Edetsberger, Martin Knapp, Erwin Gaubitzer, Christoph Miksch. Kathuna Elizbarowna Gvichiya, Gottfried Koehler (2012). Effective staining of tumor cells by coumarin-6 depends on the stoichiometry of cyclodextrin complex formation J Incl Phenom Macrocycl Chem. ;70(3):327-331.

Agócs, Gergely; Szabó, Bence T; Köhler, Gottfried; Osváth, Szabolcs (2012). Comparing the Folding and Misfolding Energy Landscapes of Phosphoglycerate Kinase. BIOPHYS J;102(12):2828-34. PMID: 22735533

Puchinger,Martin Gerald; Zarzer, Clemens Alexander; Kügler,Philip; Gaubitzer, Erwin; Köhler, Gottfried (2012). In vitro detection of adenocorticotropic hormone levels by fluorescence correlation spectroscopy immunoassay for mathematical modeling of glucocorticoid-mediated feddback mechanisms. EURASIP journal on bioinformatics & systems biology;17. PMID: 23102048


Latest Publication in EURASIP Journal on Bioinformatics and Systems Biology

Abstract: Performing quantitative, highly sensitive measurements at a single molecule level is often necessary to address specific issues related to complex molecular and...

New publication of the Köhler Gottfried group in 'Journal of Cellular and Molecular Medicine'


Biomarkers are essential part of daily medical practice. Currently, biomarkers are being used both for diagnostic and prognostic purposes. There are many approaches...