GROUP KöHLER GOTTFRIED | Biochemistry & Biophysics, Structural & Computational Biology

Biomolecular optical spectroscopy

Gottfried KOEHLER
Gottfried Koehler
Group Leader

gottfried.koehler(at)univie.ac.at
Phone: +43-1-4277-52204
Dr. Bohr-Gasse 9 (VBC 5), 1030 Vienna | Room: 1.616

Research

Biophysical characterisation of biomolecules and of their interactions in solution as well as on a live cell level represents the main object of our research. Methods include fluorescence and time resolved techniques performed over a wide range of time resolution. Studies by optical spectroscopy are complemented by biocalorimetry (DSC).

 

Quantitative studies on molecular dynamics on a single molecule level are performed using advanced fluorescence correlation techniques. Among others, these methods are applied on studies of ligand-receptor interactions relevant for hormone regulation and...

Team

Erwin Gaubitzer| Martin Gerald Puchinger| Aamir Shahzad| David Weichselbaum|

Selected Publications

Michael Edetsberger, Martin Knapp, Erwin Gaubitzer, Christoph Miksch. Kathuna Elizbarowna Gvichiya, Gottfried Koehler (2012). Effective staining of tumor cells by coumarin-6 depends on the stoichiometry of cyclodextrin complex formation J Incl Phenom Macrocycl Chem. ;70(3):327-331.

Agócs, Gergely; Szabó, Bence T; Köhler, Gottfried; Osváth, Szabolcs (2012). Comparing the Folding and Misfolding Energy Landscapes of Phosphoglycerate Kinase. BIOPHYS J;102(12):2828-34. PMID: 22735533

Puchinger,Martin Gerald; Zarzer, Clemens Alexander; Kügler,Philip; Gaubitzer, Erwin; Köhler, Gottfried (2012). In vitro detection of adenocorticotropic hormone levels by fluorescence correlation spectroscopy immunoassay for mathematical modeling of glucocorticoid-mediated feddback mechanisms. EURASIP journal on bioinformatics & systems biology;17. PMID: 23102048

News

Latest Publication in EURASIP Journal on Bioinformatics and Systems Biology

Abstract: Performing quantitative, highly sensitive measurements at a single molecule level is often necessary to address specific issues related to complex molecular and...

New publication of the Köhler Gottfried group in 'Journal of Cellular and Molecular Medicine'

Abstract:

Biomarkers are essential part of daily medical practice. Currently, biomarkers are being used both for diagnostic and prognostic purposes. There are many...