Wolfgang Schneider Lab

Defects in Receptors as Causes for Failing Fertility and Development of Atherosclerosis
 
With emphasis on receptor-mediated endocytic processes, we investigate molecular genetic, cell biological, and biochemical details of (i) receptor-mediated oocyte growth, especially lipoprotein transport via the low density lipoprotein receptor (LDLR) gene family, (ii) the molecular basis for human atherosclerosis caused by single-gene mutations that reduce receptor-mediated lipoprotein transport, and (iii) the biology of granulosa cells that surround the oocyte, e.g., their role in communication with the oocyte and the regulation of assembly of the fertilization coat containing the primary receptors for sperm.