Pavel Kovarik Lab
Signaling and gene expression in inflammation
Many immune disorders are caused by still poorly understood failures in activation or attenuation of the innate responses. We address this issue in three projects by studying responses of the innate immune system to inflammatory stimuli and infections at the level of cell signaling, transcription and mRNA decay:
1) Control of transcription by Stat proteins &
Stat transcription cycle
2) Role of mRNA decay and the mRNA-destabilizing
protein TTP in immune homeostasis
3) Responses of innate immune cells to the human
pathogen Streptococcus pyogenes
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