Quis custodiet ipsos custodies? How cells keep their guards in check
2010-07-15 18:00:00
When cells are attacked by bacteria they use all means at their disposal to defend themselves. But cellular defence systems can damage the cells themselves and so need to be kept tightly in check. Recent results help us to understand how this is done and give pointers to new ways of combating disease. Matthias Farlik in the group of Thomas Decker at the Centre for Molecular Biology of the University of Vienna (Max F. Perutz Laboratories) and Mathias Müller of the University of Veterinary Medicine, Vienna have published these findings in the current issue of the journal "Immunity". The work was funded by the Austrian Science Fund (FWF) in the framework of the Special Research Programme (SFB) “Jak-Stat-Signalling from Basics to Disease". Matthias Farlik, Benjamin Reutterer, Christian Schindler, Florian Greten, Claus Vogl, Mathias Müller and Thomas Decker Nonconventional Initiation Complex Assembly by STAT and NF-kB Transcription Factors Regulates Nitric Oxide Synthase Expression, Immunity, Vol.32, issue 7, July 2010; DOI 10.1016/j.immuni.2010.07.001 http://www.cell.com/immunity/abstract/S1074-7613%2810%2900243-8
>> Thomas Decker's group
>> Press article: derStandard online (July 18, 2010)