GROUP BACCARINI | Biochemistry & Biophysics, Developmental Biology & Disease Mechanisms, Molecular Cell Biology

Deciphering the MAPK pathway in vivo

Manuela Baccarini
Group Leader

Phone: +43-1-4277-54607
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.628


The Ras/Raf/MEK/ERK pathway represents the oldest paradigm of a cytosolic signal transduction cascade, and its constitutive activation as a result of mutations is a key event in the development of several human malignancies and developmental disorders. The Raf kinases A-, B-, and C-Raf (Raf-1) and their target MEK are attractive therapeutic targets. Yet, surprisingly little is known about their essential functions in the context of the whole organism.


Bertram Aschenbrenner| Christian Baumgartner| Clemens Bogner| Tania Brandstötter| Stefan Buchleitner| Botond Cseh| Enrico Desideri| Karin Ehrenreiter| Ines Jeric| Sanya Eduarda Kuzet| Silvia Munico Martinez| Joanna Nowacka| Cristiana Pelorosso| Josipa Raguz| Elena Rodionova| Stefanie Toifl| Andrea Varga|

Selected Publications

Zmajkovicova, Katarina,Jesenberger, Veronika, Catalanotti,Federica, Baumgartner, Christian, Reyes, Gloria und Manuela Baccarini (2013). MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance. MOL CELL. PMID: 23453810

Faculty of 1000 prime recommended

Catalanotti, Federica; Reyes, Gloria; Jesenberger, Veronika; Galabova-Kovacs, Gergana; de Matos Simoes, Ricardo; Carugo, Oliviero; Baccarini, Manuela (2009). A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol. PMID: 19219045

Faculty of 1000 prime recommended

Wimmer, Reiner; Cseh, Botond; Maier, Barbara; Scherrer, Karina; Baccarini, Manuela (2012). Angiogenic Sprouting Requires the Fine Tuning of Endothelial Cell Cohesion by the Raf-1/Rok-? Complex. Dev Cell;22(1):158-71. PMID: 22209329

Faculty of 1000 prime recommended

Collaboration & Funding

Doctoral Program "Cell Signaling"

Doctoral Program "Cell Signaling"

Baccarini co-ordinates the special Doctoral Program "Molecular Mechanisms of Cell Signaling" reviewed and funded by the Austrian Research Fund FWF.