GROUP BACCARINI | Biochemistry & Biophysics, Developmental Biology & Disease Mechanisms, Molecular Cell Biology
Deciphering the MAPK pathway in vivo
The Ras/Raf/MEK/ERK pathway represents the oldest paradigm of a cytosolic signal transduction cascade, and its constitutive activation as a result of mutations is a key event in the development of several human malignancies and developmental disorders. The Raf kinases A-, B-, and C-Raf (Raf-1) and their target MEK are attractive therapeutic targets. Yet, surprisingly little is known about their essential functions in the context of the whole organism.