GROUP DJINOVIC | Biochemistry & Biophysics, Structural & Computational Biology

Structural Biology of Cytoskeleton

Kristina DJINOVIC-CARUGO
Kristina Djinovic-Carugo
Group Leader

kristina.djinovic(at)univie.ac.at
Phone: +43-1-4277-52203
Dr. Bohr-Gasse 9 (VBC 5), 1030 Vienna | Room: 1.606

Research

We are interested in the molecular mechanisms underlying the actin-based cytoskeleton of the striated muscle. A striking feature of muscle proteins, and particularly of the specialised striated muscle sarcomere compartment Z-disk, is the high frequency of multiple protein-protein interactions. We aim to generate detailed structural information on the protein-protein interaction network in the Z-disk, from its basic components - alpha-actinin and filamin C – to macromolecular complexes and the adaptor and regulatory Z-disk proteins centred on them.

Team

Gustavo Arruda Bezerra| Oliviero Carugo| Alexej Charnagalov| Euripedes De Almeida Ribeiro| Irina Grishkovskaya| Andreas Hagmüller| Anne-Sophie HUMM| Julius Kostan| Mathias Kreuter| Michael Krutzler| Georg Mlynek| Ariadna Rodriguez Chamorro| Eduardo Henrique Salviano Bezerra| Martina Schneider| Claudia Schreiner| Antonio Sponga| Valeria Stefania| Julia Steiner| Sandra Tietscher| Karolina Zielinska|

Selected Publications

Carugo, Oliviero; Djinovic-Carugo, Kristina (2013). A proteomic Ramachandran plot (PRplot). AMINO ACIDS:1-10. PMID: 23007165

Morriswood, Brooke; Havlicek, Katharina; Demmel, Lars; Yavuz, Sevil; Sealey-Cardona, Marco; Vidilaseris, Keni; Anrather, Dorothea; Kostan, Julius; Djinovic-Carugo, Kristina; Roux, Kyle; Warren, Graham (2013). Novel bilobe components in Trypanosoma brucei identified using proximity-dependent biotinylation. EUKARYOT CELL;12(2):356-67. PMID: 23264645

Hofbauer, Stefan; Gysel, Kira; Mlynek, Georg; Kostan, Julius; Hagmüller, Andreas; Daims, Holger; Furtmüller, Paul G; Djinovi?-Carugo, Kristina; Obinger, Christian (2012). Impact of subunit and oligomeric structure on the thermal and conformational stability of chlorite dismutases. BBA-PROTEINS PROTEOM;1824(9):1031-8. PMID: 22683440

Collaboration & Funding

Doctoral Program "Structure and Interaction of Biological Macromolecules"

Doctoral Program "Structure and Interaction of Biological Macromolecules"

2009-2013: Doctoral Program "Structure and Interaction of Biological Macromolecules" reviewed and funded by the Austrian Science Fund FWF.

 
COSS - Center for Optimized Structural Studies

COSS - Center for Optimized Structural Studies

2010-2013: Laura-Bassi Center of Expertise "COSS - Center for Optimized Structural Studies" funded by the Austrian Research Promotion Agency FFG (Co-ordinator)

 
Bioinformatics Integration Network III

Bioinformatics Integration Network III

2009-2013: Research Network funded by the GEN-AU Genome Research Program of the Federal Ministry of Science and Research

 
FWF/DFG Research Unit

FWF/DFG Research Unit

2010-2014: Researc Unit 'Alpha Actinin, Filamin C and their Complexes with Binding Partners' funded by the German Research Foundation and the Austrian Science Fund

 
Marie Curie Initial Training Network

Marie Curie Initial Training Network

FWF Stand Alone Projects

FWF Stand Alone Projects

2010-2013: MORN repeat proteins and the Trypanosoma brucei bilobe (with G. Warren)

2010-2013: Structural Aspects of RAF-1:Rok-alpha Interaction (with M. Baccarini)