GROUP DJINOVIC | Biochemistry & Biophysics, Structural & Computational Biology

Structural Biology of the Cytoskeleton

Kristina DJINOVIC-CARUGO
Kristina Djinovic-Carugo
Group Leader

kristina.djinovic(at)univie.ac.at
Phone: +43-1-4277-52203
Dr. Bohr-Gasse 9 (VBC 5), 1030 Vienna | Room: 1.606

Research

We are interested in the molecular mechanisms underlying the actin-based cytoskeleton of the striated muscle. A striking feature of muscle proteins, and particularly of the specialised striated muscle sarcomere compartment Z-disk, is the high frequency of multiple protein-protein interactions. We aim to generate detailed structural information on the protein-protein interaction network in the Z-disk, from its basic components - alpha-actinin and filamin C – to macromolecular complexes and the adaptor and regulatory Z-disk proteins centred on them.

Team

Gustavo Arruda Bezerra| Oliviero Carugo| Alexej Charnagalov| Euripedes De Almeida Ribeiro| Irina Grishkovskaya| Andreas Hagmüller| Stefan Hofbauer| Anne-Sophie HUMM| Julius Kostan| Michael Krutzler| Georg Mlynek| Ariadna Rodriguez Chamorro| Sara Sajko| Eduardo Henrique Salviano Bezerra| Martina Schneider| Claudia Schreiner| Antonio Sponga| Valeria Stefania| Julia Steiner| Karolina Zielinska|

Selected Publications

Kostan J, Salzer U, Orlova A, Toeroe I, Hodnik V, Senju Y, Zou J, Schreiner C, Steiner J, Meriläinen J, Nikki M, Virtanen I, Carugo O, Rappsilber J, Lappalainen P, Lehto VP, Anderluh G, Egelman EH, Djinović-Carugo K (2014). Direct Interaction of Actin Filaments with F-BAR Protein Pacsin2. EMBO REP.

Pavšič M, Gunčar G, Djinović-Carugo K, Lenarčič B (2014). Crystal structure and its bearing towards an understanding of key biological functions of EpCAM. NAT COMMUN.

Mlynek, Georg; Lehner, Anita; Neuhold, Jana; Leeb, Sarah; Kostan, Julius; Charnagalov, Alexej; Stolt-Bergner, Peggy; Djinovi?-Carugo, Kristina; Pinotsis, Nikos (2014). The Center for Optimized Structural Studies (COSS) platform for automation in cloning, expression, and purification of single proteins and protein-protein complexes. AMINO ACIDS;46(6):1565-82. PMID: 24647677

Collaboration & Funding

Doctoral Program "Structure and Interaction of Biological Macromolecules"

Doctoral Program "Structure and Interaction of Biological Macromolecules"

2009-2013: Doctoral Program "Structure and Interaction of Biological Macromolecules" reviewed and funded by the Austrian Science Fund FWF.

 
COSS - Center for Optimized Structural Studies

COSS - Center for Optimized Structural Studies

2010-2013: Laura-Bassi Center of Expertise "COSS - Center for Optimized Structural Studies" funded by the Austrian Research Promotion Agency FFG (Co-ordinator)

 
Bioinformatics Integration Network III

Bioinformatics Integration Network III

2009-2013: Research Network funded by the GEN-AU Genome Research Program of the Federal Ministry of Science and Research

 
FWF/DFG Research Unit

FWF/DFG Research Unit

2010-2014: Researc Unit 'Alpha Actinin, Filamin C and their Complexes with Binding Partners' funded by the German Research Foundation and the Austrian Science Fund

 
Marie Curie Initial Training Network

Marie Curie Initial Training Network

FWF Stand Alone Projects

FWF Stand Alone Projects

2010-2013: MORN repeat proteins and the Trypanosoma brucei bilobe (with G. Warren)

2010-2013: Structural Aspects of RAF-1:Rok-alpha Interaction (with M. Baccarini)