GROUP DORNER | Biochemistry & Biophysics, Genetics, epigenetics & gene regulation

The regulation of gene expression by small ncRNAs

Silke DORNER
Silke Dorner
Group Leader

silke.dorner(at)univie.ac.at
Phone: +43-1-4277-54610
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.514

Research

Post-transcriptional processes such as mRNA splicing, mRNA degradation, mRNA surveillance, RNA editing, translational repression, and RNA-mediated gene silencing, play crucial roles in the regulation of eukaryotic gene expression.  In the past decade the finding of small non-coding RNAs has entirely revolutionized the way we think about the regulation of gene expression. The major focus of our research is the RNA-mediated gene silencing by siRNAs (small interfering RNAs) and miRNAs (micro RNAs) in Drosophila.  

Team

Sanja Antic| Elisabeth Jäger| Aleksandra Plotnikova| Anna Skucha|

Selected Publications

Jäger, Elisabeth; Dorner, Silke (2010). The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells. RNA BIOL. PMID: 20458171

Dorner, Silke; Lum, Lawrence; Kim, Michelle; Paro, Renato; Beachy, Philip A; Green, Rachel (2006). A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. P NATL ACAD SCI USA. PMID: 16882716

Dorner, Silke; Brunelle, Julie L; Sharma, Divya; Green, Rachel (2006). The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol. PMID: 16501572

Collaboration & Funding

Doctoral Program "RNA Biology"

Doctoral Program "RNA Biology"

Associated member of the special Doctoral Program "RNA Biology" reviewed and funded by the Austrian Research Fund FWF.

 
SFB "RNA regulation of the transcriptome (RNA-REG)"

SFB "RNA regulation of the transcriptome (RNA-REG)"

The Group Dorner is associated member of the Special Research Area (SFB) "RNA regulation of the transcriptome" funded by the Austrian Science Fund FWF. SFB's are...

Elise-Richter Career Development Grant

Elise-Richter Career Development Grant

FWF-funded grant: "The regulation of gene expression by small RNAs"

 
Joint GEN-AU Project

Joint GEN-AU Project

"Non-coding RNAs: from identification to functional characterization" - funded by the GEN-AU Genome Research Program of the Federal Ministry of Science and Research

 
FWF Stand Alone Projects

FWF Stand Alone Projects

"RNAs and Proteins associated with P-body components"

"The influence of miRNAs on mRNA degradation"

 
WWTF Stand Alone Project

WWTF Stand Alone Project

"The dynamics of the miRNA effector complex"

 
Austrian Academy of Sciences

Austrian Academy of Sciences

Since 2009 elected member of the "Junge Kurie" (Young Academy) of the Austrian Academy of Sciences.