GROUP KOVARIK | Genetics, Epigenetics & Gene Regulation, Immunology & Pathogens
Signaling and gene expression in inflammation
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.621
Scheme of IFN-induced Stat1 phosphorylation of S727. Upon IFN stimulation Stat1 becomes tyrosine-phosphorylated (pY) and translocates to the nucleus (NE=nuclear envelope). The serine phosphorylation (pS) occurs only on tyrosine-phosphorylated Stat1 molecules bound to chromatin.
The innate immune system dynamically responds to infecting pathogens by initiation of protective host responses and by a rapid termination of these responses once the infection agent is no longer present. Inefficient or uncontrolled responses may result in infectious or inflammatory diseases. We investigate both the basic principles of balanced innate immune responses as well as aspects relevant for immune disorders. The molecular mechanisms that allow a robust yet temporally precisely restricted inflammatory reaction are studied in our laboratory at the level of transcription, mRNA stability...