GroupKovarik

GROUP KOVARIK | Genetics, Epigenetics & Gene Regulation, Immunology & Pathogens

Signaling and gene expression in inflammation

Pavel KOVARIK
Pavel Kovarik
Group Leader

pavel.kovarik(at)univie.ac.at
Phone: +43-1-4277-54608
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.621

Research

The innate immune system dynamically responds to infecting pathogens by initiation of protective host responses and by a rapid termination of these responses once the infection agent is no longer present. Inefficient or uncontrolled responses may result in infectious or inflammatory diseases. We investigate both the basic principles of balanced innate immune responses as well as aspects relevant for immune disorders. The molecular mechanisms that allow a robust yet temporally precisely restricted inflammatory reaction are studied in our laboratory at the level of transcription, mRNA stability...

Team

Aleksandra Arczewska| Virginia Castiglia| Ursula Damböck| Florian Ebner| Christina Fieber (Muehlbacher)| Clemens Gaumannmüller| Masa Ivin| Marton Janos| Klemens Pranz| Vitaly Sedlyarov| Iris Steinparzer| Ivana Wiesauer (Mikulic)|

Selected Publications

Bancerek, Joanna; Poss, Zachary C; Steinparzer, Iris; Sedlyarov, Vitaly; Pfaffenwimmer, Thaddäus; Mikulic, Ivana; Dölken, Lars; Strobl, Birgit; Müller, Mathias; Taatjes, Dylan J; Kovarik, Pavel (2013). CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response. IMMUNITY. PMID: 23352233

Kratochvill, Franz; Machacek, Christian; Vogl, Claus; Ebner, Florian; Sedlyarov, Vitaly; Gruber, Andreas R; Hartweger, Harald; Vielnascher, Raimund; Karaghiosoff, Marina; Rülicke, Thomas; Müller, Mathias; Hofacker, Ivo; Lang, Roland; Kovarik, Pavel (2011). Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. MOL SYST BIOL;7:560. PMID: 22186734

Gratz, Nina; Hartweger, Harald; Matt, Ulrich; Kratochvill, Franz; Janos, Marton; Sigel, Stefanie; Drobits, Barbara; Li, Xiao-Dong; Knapp, Sylvia; Kovarik, Pavel (2011). Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection. PLOS PATHOG;7(5):e1001345. PMID: 21625574

Collaboration & Funding

Doctoral Program "Cell Signaling"

Doctoral Program "Cell Signaling"

The Group Kovarik participates in the special Doctoral Program "Molecular Mechanisms of Cell Signaling" reviewed and funded by the Austrian Research Fund FWF.

 
Doctoral Program "Cell Nucleus"

Doctoral Program "Cell Nucleus"

The Group Kovarik co-ordinates the Doctoral Program "Functional Organisation of the Cell Nucleus" funded by the University of Vienna.

 
Special Research Program "Jak-Stat Signaling"

Special Research Program "Jak-Stat Signaling"

The Group Kovarik participates in the Special Research Area (SFB) "Jak-Stat Signaling: from Basics to Disease" funded by the Austrian Science Fund FWF. SFB's are...

ERA-NET Pathogenomics

ERA-NET Pathogenomics

The Kovarik Group takes part in the ERA-NET Pathogenomics, a European research network granted by the EU.