GroupMartens

GROUP MARTENS | Biochemistry & Biophysics, Immunology & Pathogens, Molecular Cell Biology

Molecular Mechanisms of Autophagy

Sascha MARTENS
Sascha Martens
Group Leader

sascha.martens(at)univie.ac.at
Phone: +43-1-4277-61627
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 3.506

Research

Autophagy is an evolutionarily conserved and important process during which our cells digest or cannibalize small parts of themselves. Autophagy plays an essential role during starvation, the defense against pathogenic microorganisms, the removal of protein aggregates and the degradation of damaged organelles. Misregulated or defective autophagy can result in neurodegeneration and premature aging and is thus highly relevant to a plethora of human diseases.

 

Autophagy is induced by an upstream signal such as starvation, the detection of pathogenic microorganisms in the cytosol or by damaged...

Team

Christine Abert| Dorotea Fracchiolla| Nina Hobl| Veronika Nogellova| Julia Romanov| Justyna Sawa-Makarska| Bettina Wurzer| Gabriele Zaffagnini| Bettina Zens|

Selected Publications

Sawa-Makarska, Justyna; Abert, Christine; Romanov, Julia; Zens, Bettina; Ibiricu, Iosune; Martens, Sascha (2014). Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy. NAT CELL BIOL;5(16):425-33. PMID: 24705553

Romanov, Julia; Walczak, Marta; Ibiricu, Iosune; Schüchner, Stefan; Ogris, Egon; Kraft, Claudine; Martens, Sascha (2012). Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J;31(22):4304-17. PMID: 23064152

Groffen, Alexander J; Martens, Sascha; Díez Arazola, Rocío; Cornelisse, L Niels; Lozovaya, Natalia; de Jong, Arthur P H; Goriounova, Natalia A; Habets, Ron L P; Takai, Yoshimi; Borst, J Gerard; Brose, Nils; McMahon, Harvey T; Verhage, Matthijs (2010). Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. SCIENCE:1614-8. PMID: 20150444

Collaboration, Funding and Awards

EMBO Young Investigator Award 2013

EMBO Young Investigator Award 2013

Sascha Martens joins the network of EMBO Young Investigators!

 
ERC Starting Grant 2010

ERC Starting Grant 2010

Sascha Martens is awardee of a "Starting Independent Researcher Grant" from the European Research Council ERC!

 
FWF Stand Alone Project

FWF Stand Alone Project

The Martens Lab is funded by a FWF Stand Alone Grant (P25546-B20)

 
Doctoral Program "Cell Signaling"

Doctoral Program "Cell Signaling"

The Group Martens is Associated Member of the special Doctoral Program "Molecular Mechanisms of Cell Signaling" reviewed and funded by the Austrian Research Fund FWF.

 
Austrian Academy of Sciences

Austrian Academy of Sciences

Sascha Martens has been elected member of the "Junge Kurie" of the Austrian Academy of Sciences in April 2011