GROUP ZAGROVIC | Biochemistry & Biophysics, Structural & Computational Biology
Computational Biophysics of Macromolecules
The intrinsically disordered regions in nudix hydrolaze of the bacterium D. radiodurans may be an important component in the bacterium's adaptation to desiccation (Awile et al. PLOS Comp. Bio, 6, 2010).
Biological function on the molecular level is directly related to the 3-dimensional structure of biomolecules, their dynamics and finally their interactions, both with the environment as well as with other biomolecules. Conceptually, the research interests of our laboratory revolve around exploring different faces of this fundamental principle through the use of computational and theoretical methods in close collaboration with experimentalists.
While experimental approaches are making breathtaking steps forward, currently the only way to probe biomolecular structure and dynamics on a...