Group Dorner

The regulation of gene expression by small ncRNAs

Post-transcriptional processes such as mRNA splicing, mRNA degradation, mRNA surveillance, RNA editing, translational repression, and RNA-mediated gene silencing, play crucial roles in the regulation of eukaryotic gene expression.  In the past decade the finding of small non-coding RNAs has entirely revolutionized the way we think about the regulation of gene expression. The major focus of our research is the RNA-mediated gene silencing by siRNAs (small interfering RNAs) and miRNAs (micro RNAs) in Drosophila.

Publications since 2006

Antic, Sanja; Wolfinger, Michael T; Skucha, Anna; Hosiner, Stefanie; Dorner, Silke (2015). General and miRNA-mediated mRNA degradation occurs on ribosome complexes in Drosophila cells. MOL CELL BIOL;35(13):2309-20.. PMID: 25918245

Barisic-Jäger, Elisabeth; Krecioch, Izabela; Hosiner, Stefanie; Antic, Sanja; Dorner, Silke (2013). HPat a Decapping Activator Interacting with the miRNA Effector Complex. PLOS ONE;8(8):e71860. PMID: 23977167

Jäger, Elisabeth; Dorner, Silke (2010). The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells. RNA BIOL. PMID: 20458171

Dorner, Silke; Eulalio, Ana; Huntzinger, Eric; Izaurralde, Elisa (2007). Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO REP. PMID: 17599087

Eulalio, Ana; Rehwinkel, Jan; Stricker, Mona; Huntzinger, Eric; Yang, Schu-Fee; Doerks, Tobias; Dorner, Silke; Bork, Peer; Boutros, Michael; Izaurralde, Elisa (2007). Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. GENE DEV. PMID: 17901217

Dorner, Silke; Lum, Lawrence; Kim, Michelle; Paro, Renato; Beachy, Philip A; Green, Rachel (2006). A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. P NATL ACAD SCI USA. PMID: 16882716

Dorner, Silke; Brunelle, Julie L; Sharma, Divya; Green, Rachel (2006). The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol. PMID: 16501572