Phone: 0043 1 4277 54603
Research Group: http://www.mfpl.ac.at/mfpl-group/group/goerke.html
Full member of the Focus Regulatory RNA since 2015.
Full member of the DoktoratsKolleg RNA Biology since 2017.
Muna Ayesha Khan
Signal Transduction and post-transcriptional regulation in model bacteria
In recent years post-transcriptional control of gene expression by small regulatory RNAs (sRNAs) has emerged as a major principle of gene regulation in bacteria. Due to their central regulatory roles in virtually all physiological circuits, sRNA activities must be tightly controlled. This might occur either at the level of their biogenesis or turn-over. Using the GlmY/GlmZ sRNA circuit of E. coli as a model system we aim to obtain insight into these important questions. In particular, we are interested to (I) unravel the various factors and conditions controlling expression of sRNAs and (II) to identify the components of the machineries specifically controlling the decay of sRNAs.