Full member of the DoktoratsKolleg RNA Biology since 2007
Petra Pusic: “Regulation of the ncRNA CrcZ and its role in antibiotic susceptibility in Pseudomonas aeruginosa”
Muralidhar Tata: “Differentially abundant sRNAs and genes in Pseudomonas aeruginosa PA14 anoxic biofilms”
DK RNA Biology Alumni:
Alessandra Romeo: “Characterization of small non-coding RNA in Pseudomonas aeruginosa”
Hermann Hämmerle: “Function of Hfq protein in different bacteria”
The opportunistic human pathogen Pseudomonas aeruginosa is a major cause of nosocomial infections. We have previously identified P. aeruginosa regulatory RNAs that impact on virulence gene expression. Some of these sRNAs are expressed in response to nitrogen or oxygen deprivation, whereby the latter condition can become prevalent in Pseudomonas biofilms present in the lung of cystic fibrosis (CF) patients. The main focus of this project is the identification and functional analysis of regulatory RNAs as well as the elucidation of their impact on gene networks under conditions that mimic growth of the clinical Pseudomonas aeruginosa PA14 strain in CF lungs.