Special Research Program
SFB Jak-Stat Signaling: from Basics to Disease
Jak-Stat signaling is used by a large number of cell surface receptors, particularly cytokine receptors, to reprogram gene expression and to regulate many biological responses in virtually all cell types and organs. The general objective of the SFB is to jointly investigate how Jaks and Stats regulate immunity to infection, inflammation and cancer.
The unifying aim is to study these topics and the links between them. This concept is supported by similarities concerning mechanisms of acute inflammation and cancer progression, and the association of signal transduction originating from infection and inflammation with tumorigenesis. Contributions of Jaks and Stats to cell autonomous mechanisms of tumourigenesis are examined and connected to Jak-Stat contributions to cancer immune surveillance or the establishment of an inflammatory environment promoting cancer growth.
These studies consider a role for hitherto poorly understood interactions with Jak-Stat partner molecules and they will test potential functions of non-canonical Stat activation. Furthermore, they address mechanisms by which Stats regulate expression of their target genes.
University of Veterinary Medicine Vienna, Institute of Animal Breeding and Genetics
Mathias.Mueller [AT] vetmeduni.ac [DOT] at