Biochemistry & Biophysics | Genetics, Epigenetics & Gene Regulation | Structural & Computational Biology

Biogenesis and Action of small RNAs

Sebastian Falk
Group Leader

sebastian.falk [AT] univie.ac [DOT] at
Phone: +43-1-4277-74360
Campus Vienna Biocenter 5, 1030 Vienna | Room: 1.622.1

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Our group is interested in unraveling the molecular mechanisms that allow the establishment of a robust RNA interference (RNAi) response in which small RNAs are used to silence the expression of genes. We are particularly interested in understanding how the nuclear RNAi pathway leads to heterochromatin formation. We will address these questions by reconstituting and characterizing the protein complexes involved in these pathways both biochemically and structurally. For the