Genetics, Epigenetics & Gene Regulation | Nucleus & Chromosome Biology

Lamins in nuclear organization and human disease

Roland Foisner
Group Leader

roland.foisner [AT] [DOT] at
Phone: +43-1-4277-61680
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 3.113

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Lamins form a stable scaffold structure at the nuclear envelope, the lamina, and are also found throughout the nucleoplasm. They determine mechanical properties of the nucleus and are involved in chromatin regulation and gene expression. Lamin mutations cause human diseases ranging from muscular dystrophy to premature-aging syndromes. We aim at understanding molecular mechanisms of lamin functions in nuclear organization and chromatin regulation during differentiation and their




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