Developmental Biology & Disease Mechanisms | Molecular Cell Biology

Stress response in simple epithelia

Peter Fuchs
Group Leader

peter.fuchs [AT] univie.ac [DOT] at
Phone: +43-1-4277-52855
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 5.024

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A major role of the keratin intermediate filaments in simple epithelia is to protect cells from mechanical and non-mechanical stresses. There is increasing evidence for the involvement of keratin-associated proteins with the modulation of these functions. One of these proteins is epiplakin, a member of the plakin protein family. Compared to the other protein family members epiplakin has an unusual structure comprising solely 16 (mouse) or 13 (human) plakin repeat domains. Its