Molecular Cell Biology

Protein biogenesis and degradation from the ER

Natale-Erwin Ivessa
Group Leader

n-erwin.ivessa [AT] meduniwien.ac [DOT] at
Phone: +43-1-4277-61805
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 2.118


We are interested in the molecular characterization of a quality control system that operates in the endoplasmic reticulum (ER) to ensure that only properly folded proteins will be released.  Misfolded polypeptides are retro-translocated from the ER to the cytosol, where they become poly-ubiquitinated and destructed by proteasomes.  ER-associated degradation (ERAD) is of relevance for a variety of genetically inherited, neurodegenerative, and virally transmitted