Biochemistry & Biophysics | Developmental Biology & Disease Mechanisms | Molecular Cell Biology

Deciphering the MAPK pathway in vivo

Manuela Baccarini
Group Leader

manuela.baccarini [AT] [DOT] at
Phone: +43-1-4277-54607
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.628

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Constitutive activation of the RAS/RAF/MEK/ERK pathway as a result of mutations is considered a key event in the development of several human malignancies and developmental disorders. Thus, pathway components are attractive therapeutic targets. The Baccarini lab investigates the essential functions of RAF and MEK in the context of the whole organism, and on determining how the MAPK pathway is wired in vivo. Our work has revealed both kinase-dependent and kinase-independent