Biochemistry & Biophysics | Developmental Biology & Disease Mechanisms | Molecular Cell Biology

Deciphering the MAPK pathway in vivo

Manuela Baccarini
Group Leader

manuela.baccarini [AT] [DOT] at
Phone: +43-1-4277-54607
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.628

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The Ras/Raf/MEK/ERK pathway represents the oldest paradigm of a cytosolic signal transduction cascade, and its constitutive activation as a result of mutations is a key event in the development of several human malignancies and developmental disorders. The Raf kinases A-, B-, and C-Raf (Raf-1) and their target MEK are attractive therapeutic targets. Yet, surprisingly little is known about their essential functions in the context of the whole organism