Biochemistry & Biophysics | Developmental Biology & Disease Mechanisms | Molecular Cell Biology

Deciphering the MAPK pathway in vivo

Manuela Baccarini
Group Leader

manuela.baccarini [AT] [DOT] at
Phone: +43-1-4277-54607
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 4.628

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The RAF/MEK/ERK pathway is an evolutionary conserved kinase module which transduces and amplifies extracellular signals through the consecutive phosphorylation of proteins arranged in three tiers. Constitutive activation of the pathway as a result of mutations of its components or of upstream activators is considered a key event in the development of several human malignancies and developmental disorders (1). Thus, proteins in this pathway are attractive therapeutic targets