Campbell

Genetics, Epigenetics & Gene Regulation | Molecular Cell Biology

Mechanisms that ensure chromosome segregation fidelity in mitosis


Christopher Campbell
Group Leader

christopher.campbell [AT] univie.ac [DOT] at
Phone: +43-1-4277-52808
Dr. Bohr-Gasse 9, 1030 Vienna | Room: 5.610

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Research

In mitosis, chromosome segregation by the microtubule-based mitotic spindle ensures equal partitioning of the genome between the daughter cell. Cells use multiple mechanisms to ensure that chromosomes are segregated with high fidelity. The vast majority of cancer cells are aneuploid (contain the wrong number of chromosomes), indicating that one or more of these segregation fidelity mechanisms has failed. The resulting increase in chromosome segregation errors is termed

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