Martinez

Biochemistry & Biophysics | Genetics, Epigenetics & Gene Regulation | Neuroscience

Biochemistry, physiology and disease of the tRNA splicing pathway in mammalian cells


Javier Martinez
Group Leader

javier.martinez [AT] meduniwien.ac [DOT] at
Phone: +43-1-79044-4840
Bohr-Gasse 3 (IMBA Building), 1030 Vienna | Room: 7.03

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Research

In mice and humans some tRNAs are exclusively encoded as intron-containing genes, thus highlighting the importance of tRNA splicing as an essential process. Introns are excised in the nucleus by the tRNA splicing endonuclease (TSEN) complex. The resulting exon halves are subsequently ligated to generate mature tRNAs. We have combined chromatography, mass spectrometry, RNAi and phylogenetic analysis to

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